To investigate the potential regulation of Fgfr3c expression in the bovine granulosa, cells were cultured in serum-free medium with FSH or IGF-I gene expression was upregulated by FSH but not by IGF-I. Fgfr4 expression was restricted to theca cells in the follicle, and decreased significantly with increasing follicle size. Granulosa and theca cells, but not oocytes, expressed Fgfr3c, and expression in granulosa cells increased significantly with follicle estradiol content, a major indicator of follicle health. Fgf8 expression was detected in oocytes and in granulosa and theca cells this expression pattern differs from that reported in rodents. RT-PCR was used to analyze bovine Fgf8, Fgfr3c and Fgfr4 mRNA levels in oocytes, and granulosa and theca cells. In the present study, we tested the hypothesis that FGF-8 and its cognate receptors (FGFR3c and FGFR4) are expressed in bovine antral follicles. Finally, I make use of Walter Benjamin’s notion of “constellation" to highlight the ethical proposal implicit in Mouawad’s work.Paracrine cell signaling is believed to be important for ovarian follicle development, and a role for some members of the fibroblast growth factor (FGF) family has been suggested. In the second part, I put Kafka’s oeuvre together with Scorched in order to reflect on the agonism of silence and song-or chant-that traverses the experience of Mouawad’s characters. I also include some fragments from Mouawad’s play as examples of a kind of writing that juxtaposes times and meanings which overtake the linearity of history. In the first section of this paper, I contrast the notions of origin articulated by Walter Benjamin and by the human sciences or commo-n sense. Therefore, a childhood that acts to prevent the conclusiveness of history and to assert its capacity to unfold along different trajectories is an insurgency that interrupts time and history’s linearity. Benjamin’s is a childhood that operates through trials and peculiar modes of reading and writing which put obedience and reproduction as features of a mythical universe to the test.
Benjamin’s contribution to an understanding of childhood helps us to think how infantile dauntlessness can confront the mythical forces of literature. Borrowing from Walter Benjamin’s thought, the central literary question in the play is to consider origin as a mythical creation.
This paper aims to present a reflection on the ethical implications of the notion of origin – a construct understood in the human sciences in the sense of cause, source, beginning-by way of a dialogue with Wadji Mouawad’s stage play Scorched.
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